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Breck leads a wagon train of pioneers through Indian attack, storms, deserts, swollen rivers, down cliffs and so on while looking for the murder of a trapper and falling in love with Ruth.
Breck Coleman leidt honderden pioniers in een trein van de Mississippi rivier tot aan het Wilde Westen. Onderweg krijgt Coleman te maken met Indianen, de droogte van de woestijn en wordt hij verliefd op een van de passagiers.
Pioneers heading for Oregon endure the hardships of weather, unfriendly strangers and internal strife in this sophisticated early sound film. Featuring John Wayne in his first starring role, this straightforward Western tale is now overshadowed by its place in history as an early example of Fox's widescreen Grandeur process, its naturalistic sound, and prototypical Wayne performance.