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In a world filled with Mad Scientists and Evil Inventions, one talented evil scientist's hunch-backed lab assistant has big dreams of becoming a Mad Scientist himself and winning the annual Evil Science Fair.
Lab assistant Igor (John Cusack) dreams of becoming a mad scientist like his master, Dr. Glickenstein. When the doctor runs afoul of his own invention, Igor seizes the chance. With the help of his friends Scamper (Steve Buscemi) and Brain (Sean Hayes), Igor plans to win the kingdom's annual science fair by building the most-evil monster ever. The problem is that Eve (Molly Shannon), as the monster is called, is sweeter than sugar and would rather be an actress.
John Cusack leads an all-star voice cast featuring Jay Leno, Molly Shannon, John Cleese, Jeremy Piven, Steve Buscemi, and Jennifer Coolidge in this computer-animated comedy about a gifted scientist who happens to have been born with a most unfortunate deformity. Igor (voice of Cusack) may have been born with a brilliant mind, but unfortunately everyone around him is too distracted by his pronounced hunchback to notice. Forced to serve as a lowly lab assistant to nefarious scientist Dr. Glickenstein (voice of Cleese), Igor longs for the day he will become a mad scientist, take top prize at the Evil Science Fair, a...
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nd finally win the heart of village vixen Gretchen. Every year, mad scientists from all of the local villages converge on Malaria to compete in the annual Evil Science Fair -- an event that always features an abundance of death rays, earthquake generators, and man-eating plants. This year, Igor's village manages to take the top prize, too. But despite the fact that his lab receives a substantial government reward, the king confiscates the invention to be used in Malaria's defense program. Unlike the other Igors, this hunchbacked genius longs to change the world in ways his master could have never imagined, and when Dr. Glickenstein dies just two weeks before the latest Evil Science Fair, Igor seizes the opportunity to shine.
Carefully covering up Dr. Glickenstein's death, Igor enlists the aid of angry brain-in-a-jar Brian and insecure re-animated rabbit Scamper to create an enormous, hideous creature of unparalleled strength. Trouble arises, however, when the creature turns out to be a female monster with a heart of gold. Unable to comprehend the concept of evil, the creature believes that Igor has named her "Eva," and longs for the day she will become a respected actress. With the Evil Science Fair fast drawing near, Igor has just two weeks to turn Eva the sweetheart into Evil the rampaging nightmare. Now, in order to win the competition, Igor works tirelessly to convince Eva that the Evil Science Fair is actually an audition for a twisted stage version of Annie, and that in order to win the lead role she must immerse herself in the evil character and never reveal her inner goodness. But as the "rehearsals" get underway, the nosy villagers come snooping around the castle, the malevolent Dr. Schadenfreude schemes to claim Eva as his own, and Igor slowly starts falling in love with his creation while realizing that life as a mad scientist may not be so glamorous after all.
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De film draait om Igor, de gebochelde lab-assistent van een doldwaze wetenschapper. Hij heeft zelf grote dromen om ooit eens net zo'n wetenschapper als zijn chef te worden, en de eerste prijs te winnen van de jaarlijkse "Evil Science Fair". Hij creëert daartoe "Eva", die bedoeld is om als 'monster' het daglicht te zien. Echter de zaken lopen niet zoals ze vooraf ingeschat zijn. En Eva houdt eigenlijk meer van dansen en wil actrice worden...